Substance Use · United States
U.S. drug overdose deaths dropped for third straight year in 2025
CDC data show overdose deaths fell nearly 14% in 2025, attributed in part to naloxone availability and declines in synthetic opioids.
Reuters reports that U.S. drug overdose deaths fell nearly 14% in 2025, the third consecutive annual decline, with most states experiencing decreases. New Mexico, Arizona, and a handful of other states bucked the trend.
Public health officials credit broader naloxone distribution and declines in synthetic opioid deaths, while cautioning that totals remain historically high.
Read the full Reuters report for the state-by-state breakdown and CDC context.
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